A population pharmacokinetic dosing tool built for clinical decision support in the ICU. Enter patient demographics and labs, select from 10 antibiotics, and instantly visualize individualized concentration-time profiles with target attainment analysis.
Designed by a critical care pharmacist and built to bridge the gap between PK theory and bedside dosing.
Open CalculatorEnter patient demographics and labs to instantly compute pharmacokinetic parameters, concentration-time profiles, and target attainment for 10 antibiotics.
Every dose change recalculates in real time — watch the concentration curve reshape as you adjust dose, frequency, and infusion time.
Six interactive teaching modules take you from basic compartment models to clinical dose optimization — all with live simulations you can manipulate.
Compare intermittent, extended, and continuous infusion strategies for beta-lactam antibiotics. See how changing the infusion duration reshapes the concentration-time curve and impacts fT>MIC target attainment — all with the same total daily dose.
Explore Strategies →Drug-specific pharmacodynamic targets from the literature: time-dependent, concentration-dependent, and AUC-dependent killing patterns with MIC-based thresholds.
View PD Targets →Full formula reference for every equation used in the calculator — clearance, volume of distribution, renal function estimates — all rendered with mathematical typesetting.
View Calculations →Continuous renal replacement therapy dosing for 20 drugs with sieving coefficients, non-renal clearance parameters, and effluent rate-based dose calculations.
Open CRRT →Vancomycin and aminoglycoside measured-level assessments with AUC calculations, dose recommendations, and Hartford nomogram for interval determination.
Open Two-Level PK →Published pharmacokinetic studies used to derive clearance, volume of distribution, and protein binding for each antibiotic — with direct PubMed links.
View References →The story behind the tool and the father-son team that built it: a critical care clinical pharmacist and a software developer working together.
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